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The association of MS with liver, pancreatic, gastric, colorectal, bladder, prostate, endometrial, cervical, and postmenopausal breast cancers have all been reported. There is increasing evidence to indicate that MS might play an important role in the etiology and progression of certain types of cancers. In 1998, the World Health Organization (WHO) recommended a unifying definition and revised this in the following year: impaired glucose regulation and/or hyperinsulinemia (fasting glucose ≥110 mg/dl post-prandial glucose >140 mg/dl fasting serum insulin: third quartile for control group) and two or more criteria are necessary: (1) hypertension, ≥140/≥90 mmHg (2) hypertriglyceridemia, ≥150 mg/dl low HDL levels - male 0.90, female >0.85, and/or body mass index (BMI) ≥30 kg/m 2 (4) microalbuminuria, ≥20 μg/min. For example, NCEP/ATP III (National Cholesterol Education Program/Adult Treatment Panel III) sets three of five of the following criteria as necessary for a diagnosis of MS: fasting glucose ≥110 mg/dl hypertriglyceridemia ≥150 mg/dl low high-density-lipoprotein (HDL) levels - male 102 cm, female >88 cm waist circumference hypertension, ≥130/≥85 mmHg. Because IR is not easily measured clinically, it is not included in all of the definitions developed by different organizations, whereas abdominal obesity, dyslipidemia, hypertension, and impaired glucose regulation have been adopted in almost all of the diagnostic criteria. With a deeper understanding of MS, more sophisticated mechanisms have been revealed, and IR is recognized as one of the most significant factors. It comprises a cluster of metabolic abnormalities, each of which is an important atherosclerotic risk factor. MS was first described using the term ‘syndrome X’ by Reaven in 1988, with insulin resistance (IR) as the common and elementary denominator. This review summarizes evidence in support of the relationship between MS and renal cell carcinoma (RCC) and possible underlying mechanisms and therapeutic interventions. Recently, the relationship between MS and cancer has been highlighted by the observation that MS is associated with high morbidity and mortality for certain types of cancer. The concern regarding MS was primarily focused on its contribution to increased cardiovascular disease and type 2 diabetes mellitus risk. According to an analysis of data in 2005, up to 20% Chinese adults suffered from MS.
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Over recent decades there has been an alteration of dietary pattern and lifestyle in Chinese people, and subsequently an elevated morbidity associated with MS year by year. residents over the age of 60 years have MS, with a prevalence of approximately 25% in European and Latin populations. Metabolic syndrome (MS) has become an almost ubiquitous severe health issue across the globe.